Table 1

Interactive effects of Dexamethasone and Hb:Hp-on monocyte gene expression

Interactive effects of Dexamethasone and Hb:Hp-on monocyte gene expression

The table shows the 47 genes identified by the gene array analysis described in Figure 4. These genes were significantly co-regulated by dexamethasone priming and Hb:Hp exposure and were induced >1.5-fold in dexamethasone-primed cells. The graph on the right shows the corresponding gene expression changes (log ratio; mean ± error, n=4) induced by Hb:Hp in either dexamethasone pretreated (red) or nontreated (black) monocytes. Note that almost all genes on this list exhibit greater induction or suppression in monocytes pretreated with dexamethasone. Black arrows indicate genes known to be regulated by the Nrf-2–Maf/MARE signaling pathway. White arrows indicate genes with functions related to Hb, heme, or iron metabolism.

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