Evolution of anti-SIV specific immune responses in PEG-IFN-α– and R-sIL-7gly–treated macaques. (A) CD8⁺ TCM cell counts measured in macaques 6 and 7 (top panel; gray and black bars, respectively) treated with weekly injections of PEG-IFN-α (135 μg/kg) for a total of 10 weeks and macaques 8 and 9 (bottom panel; gray and black bars, respectively) treated with weekly injections of PEG-IFN-α (135 μg/kg) and 4 injections of R-sIL-7gly (80 μg/kg) once every 3 weeks for a total of 10 weeks. (B) Plasma viral load measured throughout the follow-up period in macaques 6 and 7 (top panel; white diamonds and triangles, respectively) and macaques 8 and 9 (bottom panels; black diamonds and triangles, respectively). (C) Percentage of PD-1–expressing CD8⁺ TCM cells in macaques 6 and 7 (top panel; white diamonds and triangles, respectively) and macaques 8 and 9 (bottom panels; black diamonds and triangles, respectively).