Evolution of T-cell diversity in PEG-IFN-α– and R-sIL-7gly–treated macaques. (A) Evolution of the sj/βTREC ratio measured in macaques 1 and 2 (left panel; white circles and squares, respectively) treated with weekly injections of PEG-IFN-α (35 μg/kg) for a total of 10 weeks, macaques 6 and 7 (central panel; white diamonds and triangles, respectively) treated with weekly injections of PEG-IFN-α (135 μg/kg) for a total of 10 weeks, and macaques 8 and 9 (right panel; black diamonds and triangles, respectively) treated with weekly injections of PEG-IFN-α (135 μg/kg) and R-sIL-7gly (80 μg/kg) every 3 weeks for a total of 10 weeks. (B) T-cell repertoire diversity estimated as 1/quadratic distances to a healthy control monkey in macaques 1 and 2 (left panel; white circles and squares, respectively), macaques 6 and 7 (middle panel; white diamonds and triangles, respectively), and macaques 8 and 9 (right panel; black diamonds and triangles, respectively).