High-dose IFN-α therapy induces increased T-cell counts. Circulating blood CD3⁺ (left panels), CD4⁺ (middle panels), and CD8⁺ (right panels) T-cell counts measured (A) in macaques 8 and 9 (top panels; black diamonds and triangles, respectively), treated with weekly injections of PEG-IFN-α alone (135 μg/kg) and 4 injections of R-sIL-7gly (80 μg/kg) once every 3 weeks, for a total of 10 weeks and (B) in macaques 6 and 7 (bottom panels; white diamonds and triangles, respectively) treated with weekly injections of PEG-IFN-α (135 μg/kg) for a total of 10 weeks.