Uric acid and caspase-1 are dispensable for fibrin ET formation. (A) Mice were treated with uricase or PBS on day −1 and also 10 minutes before Alhydrogel injection. After 5 hours, fibrin ETs were weighed. (B) Peritoneal lavage fluid from each mouse in panel A was centrifuged to remove cells, and then the supernatant was tested for uric acid. Naive indicates mice that were never injected with PBS, uricase, or Alhydrogel. *P < .05 compared with PBS alone. (C) At 5 hours after Alhydrogel injection, caspase-1 KO mice and littermate controls were tested for fibrin ET formation. All experiments included at least 3 mice per group and were performed at least 3 times.