Effect of eliglustat tartrate on plasma biomarker levels over time. Data are reported as the medians (for the non-normally distributed data) and 95% CI. *P < .001 for comparison of median change or median percentage change from baseline. The normal reference range is less than 2 to 6 μg/mL for plasma GL-1 and 5.0 to 9.2 μg/mL for plasma GM3.