CD21^−/lo B cells from RA and CVID patients display a phenotype reflecting gene array profiling data. Overlays for the indicated markers were obtained when CD27-depleted B cells isolated from the blood of patient RA01 were gated on either CD19⁺CD21^−/lo (bold line) or CD19⁺CD21⁺ (dashed line) B cells. The similar phenotypes of CD21^−/lo B cells from CVID patients and healthy donors are shown in supplemental Figures 7 and 8.