Model on miRs deregulated in CLL with 17p deletion. p53 targets are deregulated in cases with 17p deletion and TP53 mutation. Based on the work presented in this issue, additional miRs (miR-21, miR-181, miR-155, miR-497, and miR-15a) are differentially expressed in CLL with and without 17p deletion. Downstream targets potentially mediating clinical consequences of deregulation of these miRs in CLL are currently unknown.