Comparison of the histopathologic changes in organs from septic animals with or without compstatin treatment during the first (T0) or second (T + 5) stage. The tissues were collected after euthanasia at T + 24 hours. Evaluations of the parameters were performed in a blinded fashion and graded on a scale from 0 to 4, with 0 being normal and 4 being severe. The histopathologic changes of the tissues collected from the 2 compstatin-treated groups are significantly less severe than those of the E coli challenge group. P < .001, with the exception of the lung congestion. Data are presented as mean ± SEM; 2-tailed Student t test. *P < .05; **P < .01; ***P < .001.