Kaplan-Meier survival curves. OS (A) and RFS (B) in 121 CN-AML patients based on scoring system (P < .001 for both OS and RFS). CN-AML patients were grouped according to scoring system based on 4 prognostic markers (CEBPA^{double-mutation}, NPM1/FLT3-ITD, WT1 mutation, and age). A score of −1 was assigned for each parameter associated with a favorable outcome (CEBPA^{double-mutation} and NPM1^mut/FLT3-ITD⁻) and a score of 1 for each factor associated with an adverse outcome (WT1 mutation and older age). The algebraic summation of these scores of each patient was the final score.