Myeloid expansion in myr-AKT mice. (A) Kaplan-Meier survival curve of 3 separate BMT experiments using myr-AKT retrovirus (n = 30) or MIG empty vector control (n = 5; P < .001). (B) Hematoxylin and eosin–stained histopathology sections of a representative liver and spleen of myr-AKT recipients, revealing infiltration with immature myeloid and erythroid cells (arrows). Details on image acquisition can be found in supplemental Methods. To the left is a photograph of spleens from myr-AKT and MIG control mice. (C) Flow cytometric analysis of the myeloid, lymphoid, and erythroid lineages of BM and spleen (SP) single-cell suspensions from myr-AKT or MIG transplantation recipients. All were gated for GFP⁺ cells. Values are the mean ± SEM. *P < .05.