Motifs associated with BCL6 binding and their distribution across promoters. (A) DNA sequence analysis of BCL6 bound promoters as detected by ChIP-on-chip revealed enrichment for 3 motifs (M00424, M2, and M0), of which 1 (M0) resembles previously reported BCL6 binding sequences (B6BS, BCL6). (B) The module including M0, M00424, and M2 within 375 bp is found in the majority of BCL6-bound promoters, the M0 motif has sites in the promoters of the majority of the remaining genes, and almost half of the M0-free promoters display Inr elements. BCL6 is known to repress some of its targets upon interaction with Miz-1, which binds to Inr elements.