LAIR-1 overall structure and comparison with other LRC-family members. (A) Ribbon drawing of the LAIR-1 ectodomain structure in rainbow colors from N-terminus (blue) to C-terminus (red). The disulfide bond between β-strands B and F, characteristic of Ig-like domains, is indicated in stick representation. (B) Superposition of the LAIR-1 ectodomain (gray) with the D1 domains of LRC-family members KIR2DL2, GPVI, LIR1, and the Fc-alpha receptor, respectively (red).