Conversion from naive to effector/effector memory T-cell phenotype after double-cord CBT. (A) CD8⁺ and CD4⁺ T cells in a representative unmanipulated fresh cord blood express a naive phenotype (CCR7⁺CD45RO⁻). (B) In a representative sample of day 14 posttransplantation PBMCs, CD8⁺ T cells express a primarily effector/effector memory phenotype (CCR7⁻CD45RO^+/−), and CD4⁺ T cells express primarily naive (CCR7⁺CD45RO⁻) and central memory (CCR7⁺CD45RO⁺) phenotypes.