Cumulative incidence and hazard ratios (HRs) of main outcomes according to D-d time course from the third month (T90) to the 13th month (T390). Group 1: Patients in whom D-d was normal at T90 and afterward (with D-d becoming abnormal only once). Group 2: Patients in whom D-d became abnormal at T90 and afterward remained altered persistently or at least twice. Group 3: Patients in whom D-d became abnormal after T90 and afterward remained abnormal persistently or at least twice.