TG parameters in patients with LACs. (A) Box-and-whisker plots for the PH/LT ratio, measured in healthy controls (n = 25) and in patients with persistent LACs, without (group 1, n = 8) or with (group 2, n = 8) evidence of thrombosis, compared with patients with LAC negative for thrombosis (group 3, n = 21). The central box represents the 25th and 75th percentiles and the middle line represents the median. The vertical black line extends from the minimum to the maximum value, outliers being displayed as separate points. The light lines represent the 1 SD group intervals. P values, calculated with the Mann-Whitney test, are represented for comparisons between experimental groups. (B) Box-and-whisker plots for normalized PH/LT ratio, for patients with persistent LACs (n = 54) with reduced PH/LT ratio, in multiple dilutions with NPP (1:2 to 1:20). The gray line represents the cutoff value for the PH/LT ratio (0.9). (C) Box-and-whisker plots for normalized PH/LT ratio, measured for patients with persistent LACs (n = 54) with reduced PH/LT ratio, with or without TECs; patient plasma is diluted 1:2 with NPP. The gray line represents the cutoff value for the PH/LT ratio (0.9). P value, calculated with the Mann-Whitney test, represents the comparisons between the 2 patient groups.