Figure 4
Anti-A20 Id mAb + CpG combination therapy can cure large established A20 tumors. (A) Balb/c mice were inoculated with 107 A20 cells subcutaneously. Therapy began when tumors were 1 cm2 (day 0; as indicated by the arrows). Anti-A20 Id mAb was administered intraperitoneally on day 0, and CpG was administered intratumorally on days 2, 3, 4, 6, and 8 (P < .001). Numbers in parentheses indicate animals cured by therapy. (B) Photographs were taken of mice (on day 15) shown in panel A demonstrating that anti-A20 Id mAb + CpG combination therapy was superior to CpG or antibody alone in curing mice of large established tumors. The mice in each panel are representative of the group from which they are taken.
