Figure 2
Relationships of MGCD0103 Cmax and AUC with dose. Pharmacokinetic parameters were derived using noncompartmental methods with WinNonlin Professional (Pharsight). (A,B) Cmax dose profiles for day 1 and day 12. (C,D) Individual AUC(0-24) dose relationships for day 1 and day 12 after MGCD0103 treatment 3 times per week. (E,F) Individual T½ profiles on day 1 and day 12. (G,H) Individual Tmax profiles on day 1 and day 12.

Relationships of MGCD0103 Cmax and AUC with dose. Pharmacokinetic parameters were derived using noncompartmental methods with WinNonlin Professional (Pharsight). (A,B) Cmax dose profiles for day 1 and day 12. (C,D) Individual AUC(0-24) dose relationships for day 1 and day 12 after MGCD0103 treatment 3 times per week. (E,F) Individual T½ profiles on day 1 and day 12. (G,H) Individual Tmax profiles on day 1 and day 12.

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