Figure 2
Figure 2. Oligoclonality of Vδ1, but not Vδ2, repertoire was more pronounced in CMV+ compared with CMV− subjects. Profiles of Cδ-Vδ1 (A) and Cδ-Vδ2 (B) CDR3 length distribution were obtained by Immunoscope analysis of the PBMCs of 10 CMV− and 10 CMV+ donors. (Left panels) Fluorescence intensity is represented in arbitrary units as a function of the size of single-stranded DNA fragments. (Right panels) The index of clonality for each patient studied was calculated as indicated in “Analysis of TCR CDR3-length distribution by Immunoscope” and plotted as a function of the donor CMV (top panels) or HSV (bottom panels) serology status. HSV serology could not be determined for one CMV-seropositive donor, explaining why only 19 donors are plotted in the bottom panels. Means are indicated by a short line.

Oligoclonality of Vδ1, but not Vδ2, repertoire was more pronounced in CMV+ compared with CMV subjects. Profiles of Cδ-Vδ1 (A) and Cδ-Vδ2 (B) CDR3 length distribution were obtained by Immunoscope analysis of the PBMCs of 10 CMV and 10 CMV+ donors. (Left panels) Fluorescence intensity is represented in arbitrary units as a function of the size of single-stranded DNA fragments. (Right panels) The index of clonality for each patient studied was calculated as indicated in “Analysis of TCR CDR3-length distribution by Immunoscope” and plotted as a function of the donor CMV (top panels) or HSV (bottom panels) serology status. HSV serology could not be determined for one CMV-seropositive donor, explaining why only 19 donors are plotted in the bottom panels. Means are indicated by a short line.

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