Accelerated short-term hematopoietic reconstitution by Ndn-deficient HSCs. (A) Short-term advantage in reconstitution capacity of Ndn^+m/−p KSL cells in vivo. Irradiated recipient mice were transplanted with 1 × 10³ KSL cells from Ndn^+/+ or Ndn^+m/−p mice plus 4 × 10⁵ competitor cells in a competitive assay. Data shown are the mean percentage ± SD of donor-derived cells (total, myeloid, B-lymphoid, and T-lymphoid lineage) in the peripheral blood at the indicated times after transplantation (n = 7). *P < .05. **P < .01. (B-C) Enhanced hematologic regeneration capacity of Ndn^+m/−p KSL cells. Irradiated recipient mice were transplanted with 500 KSL cells from Ndn^+/+ or Ndn^+m/−p mice in a noncompetitive assay. The count of (B) white blood cells (WBC) and (C) platelets in the peripheral blood of recipient mice was determined at the indicated times after transplantation. Data shown are mean number ± SD (*P < .05, **P < .01, Ndn^+/+: n = 9, Ndn^+m/−p: n = 10).