Dose-dependent response to αDEC-205-EBNA1 targeting. Monocyte-derived DCs were pulsed with increasing concentrations of αDEC-205-EBNA1 (■) or Ig-EBNA1 (♦) control antibodies using poly(I:C) as a maturation stimulus. PBMCs from the same donor were stimulated with the antigen-loaded and matured DCs for 9 days, and frequencies of EBNA1-specific IFN-γ⁺ CD3⁺ T cells were determined by intracellular staining after EBNA1 peptide restimulation. One of 2 evaluated donors is shown.