CYBB gene expression in EBV-transformed B-cell lines. Cell lines were derived as follows: lane 1, healthy donor; lane 2, a patient with X-linked with CGD; and lanes 3 and 4, the designated patients with EDA-ID. CYBB gene expression by EDA-ID cells was significantly lower than that in the normal cell line (P < .05, n = 6, Mann-Whitney test) and equivalent to that in the X-linked CGD cell line.