DNA methylation in patients with AML at diagnosis and relapse. Patients are arranged horizontally, genes vertically. Average methylation densities of 0% to 10% are shown in green (0%-15% for PGRB), 10% to 50% methylation in yellow (15%-50% for PGRB); and methylation over 50% in red. NR, no result. We observed increased methylation in AML at diagnosis in 144 of 295 data points and in 175 of 294 data points at relapse.