Loss of anti-inflammatory potency of VAG539 in AhR-deficient mice. Allergic lung inflammation was induced in wild-type or AhR^−/− mice in the absence or presence of VAG539 treatment and serum IgE levels (top), eosinophilia (middle), and IL-5 (bottom) in the bronchoalveolar fluid were measured. sem indicates standard error of the mean (*P < .05. **P < .01).