VAF347 inhibits cytokine induced IL-6 production in MonoMac1 cells. Top row: induction of CYP1A1 mRNA expression measured by qRT-PCR on treatment with VAF347 and TCDD in the absence or presence of IL-4 and GM-CSF; bottom row: inhibition of IL-4 plus GM-CSF–induced IL-6 transcription by the 2 AhR agonists. The expression levels of CYP1A1 and IL-6 relative to the housekeeping gene eF-1α are depicted. Error bars represent SD.