Figure 5
Figure 5. Early adoptive transfer of ETCs is associated with improved leukemia-free survival at the expense of severe GVHD. Mixed (MC) and full chimeras (FC) were challenged with 0.6 × 106 C1498 cells intravenously on day 20. On day 21, the recipients were treated with 40 × 106 effector cells. As effectors either (A) ETCs:R-DCspulsed (-♦-, n = 9), (B) ETCs:D-DCspulsed (-♦-, n = 9), or (C) ETCs:R-DCsnonpulsed (-◇-, n = 9) were adoptively transferred by tail vein injection. Naive DLI (-■-, n = 8) and PBS (-▴-, n = 9) were used as controls. Survival was monitored in MC and FC recipients for 100 days after treatment. Deaths due to GVHD are indicated by an asterisk. Pooled data from 2 independent experiments are shown. P values are added to the figure. P less than .05 was considered to be significant.

Early adoptive transfer of ETCs is associated with improved leukemia-free survival at the expense of severe GVHD. Mixed (MC) and full chimeras (FC) were challenged with 0.6 × 106 C1498 cells intravenously on day 20. On day 21, the recipients were treated with 40 × 106 effector cells. As effectors either (A) ETCs:R-DCspulsed (-♦-, n = 9), (B) ETCs:D-DCspulsed (-♦-, n = 9), or (C) ETCs:R-DCsnonpulsed (--, n = 9) were adoptively transferred by tail vein injection. Naive DLI (-■-, n = 8) and PBS (-▴-, n = 9) were used as controls. Survival was monitored in MC and FC recipients for 100 days after treatment. Deaths due to GVHD are indicated by an asterisk. Pooled data from 2 independent experiments are shown. P values are added to the figure. P less than .05 was considered to be significant.

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