Inactivation of Icmt improves survival and reduces autonomous colony growth of hematopoietic cells in a second model of K-RAS–induced malignancies. (A) Survival of Icmt^fl/+K^LSLLC (n = 24), Icmt^fl/flK^LSLLC (n = 14), and control (n = 10) mice. Methylcellulose colony assay of bone marrow cells (B) and splenocytes (C) (n = 3 for each genotype) cultured in the absence of exogenous growth factors. (D) Photographs from typical experiment in panel C.