Functional consequences of miRNA inactivation by PML-RARA. (A) cDNA profiles obtained by microarrays (recapitulated in Tables S2 and S3) were compared with the data indicated in Table 1 in order to determine the number of targeted mRNAs and the number of targeting miRNAs per mRNA. (B) List of 4 down-regulated mRNAs targeted by 10 or more miRNA candidates. (C) RT-qPCR directed against the uPAR mRNA performed on RNAs used in panel A. (D) Schematic representation of the uPAR 3′ UTR and the targeting miRNAs. The miRNA::mRNA hybrids are indicated.