Dose effect of Syk inhibition on mTOR activity in malignant B-cells. Syk-dependent activation of mTOR was evaluated in MCL (Granta-519 and Rec-1), DLBCL (DEAU and LIB), and Burkitt (Raji) cell lines using antiphospho-p70S6K antibody. p70S6K was used as control of protein expression. Results are representative of 3 independent experiments.