Comparative in vivo antitumor activity of dasatinib and imatinib in the intracranial K562-pLUC#2 CML model and plasma/brain pharmacokinetic profile of dasatinib. (A) Tumor growth inhibition by dasatinib or imatinib in the K562-pLUC#2 intracranial model as determined by BLI. Treatment was initiated on day 6 after tumor cell implantation. x indicates days of dasatinib administration. Mean photon emission plus or minus SE for each treatment set is shown (n = 8-9 mice per set). (B) Regression of large, well-established intracranial K562-pLUC#2 tumors by dasatinib treatment as determined by BLI (study 3). Treatment was initiated on day 9 after tumor cell implantation. x indicates days of drug treatment. Mean photon emission plus or minus SE for each treatment set is shown (n = 8 mice per set). (C) Plasma and brain pharmacokinetic profile for dasatinib. Each data point on the graph represents the average of 3 mice. Mice were killed at the indicated time, and plasma was prepared from whole blood obtained by cardiac puncture; brain biopsies were obtained from the same animals matching the plasma samples.