Antiviral response to MCMV infection. (A) Animals were injected intraperitoneally with GFP-recombinant MCMV. At 1.5 days after challenge, the frequencies of pDCs and MCMV-infected DCs were measured in the spleen, and cytokines were titrated in the serum. *P = .005; **P = .001. (B) Distribution of pDCs (Ly-6C⁺ 120G8⁺) in WT and Ik^L/L spleens following infection. Contour plots are gated on CD11c⁺ cells. Numbers indicate percentage of gated cells in each plot. (C) Proportion of GFP⁺ WT and Ik^L/L spleen cells after infection. Results shown are representative of 5 experiments, each with 3 to 12 mice per group. Means and SDs are shown for 1 representative experiment.