Induction of apoptosis by oxaliplatin and fludarabine in CLL lymphocytes. CLL lymphocytes were treated with concentrations of oxaliplatin (A) (1, 5, 10, 25, 50, 100 μM) or fludarabine (B) (1, 2.5, 5, 10, 25, 50 μM) for 24 hours or with 5 μM oxaliplatin (C) or 2.5 μM fludarabine (D) for 24 hours. Annexin V–positive cells were considered apoptotic, presented as the percentage of apoptotic cells, and expressed as the mean ± SE. The results are the means of 3 experiments.