Fig. 4.
![Fig. 4. Rolipram raises cAMP levels in CLL cells, WMC, and resting B cells. One million freshly isolated cells were incubated with the indicated drugs for 2 hours before analysis of cAMP in cell lysates using a radioimmunoassay. Data are the mean of three individually assayed culture wells. In (D), vinpocetine was added at 30 μmol/L. The experimental conditions indicated with an asterisk had a greater [cAMP] than, as appropriate, the untreated or forskolin-treated control cells (t-test: one-tailed significance level <.05).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/92/7/10.1182_blood.v92.7.2484/3/blod41921004x.jpeg?Expires=1724272220&Signature=vRL1GSnVCaWuPz9c77N1wT4GqMZJr0SpQjyHpnIdZPOaUVJX~5AWoIy-44DyjfsJVjDSpdAM0~dvmVTYSIjrNYg920To17-ULseGvrv60hztR3w5FOXMme061xaF0N2xEd3gfoPutJAjS99fS850HKvn9fjT-AUBCyJ79AlKEDuGtH9ckB-L9XbFZx8oxIiUwK7tTfKYMqp1WMoXG8Q4z2HUwh25d7Orn~5TsNeOtUaKOV187UVKQNm4HDTEXZXfcXT0Ik~DT1OP~gBWuqVkBEgs8~w8A2flFwdNuImP54t5i1-e4ZuAu9qgmBGNodjEbE2M5w89qj1MX0FhctBkfA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Rolipram raises cAMP levels in CLL cells, WMC, and resting B cells. One million freshly isolated cells were incubated with the indicated drugs for 2 hours before analysis of cAMP in cell lysates using a radioimmunoassay. Data are the mean of three individually assayed culture wells. In (D), vinpocetine was added at 30 μmol/L. The experimental conditions indicated with an asterisk had a greater [cAMP] than, as appropriate, the untreated or forskolin-treated control cells (t-test: one-tailed significance level <.05).
