Survival was measured from birth up to each age. The probabilities of relatives with normal laboratory tests or with antithrombin, protein C, protein S deficiencies, or factor V Leiden were calculated by Kaplan-Meier analysis. The total number of events/number of subjects at risk was 14 of 258 for relatives without defect, 29 of 85 for antithrombin, 18 of 64 for protein C, 15 of 40 for protein S deficiency, and 35 of 197 for factor V Leiden.