Fig. 2.
![Fig. 2. Electron microscopic analysis of the microvasculature of Syk-deficient mice. / Compared with panel A (wild-type [wt]), panel B shows remarkable morphologic abnormality and decreased numbers of ECs in Syk-deficient mice (Syk−). Arrowheads highlight the scanty cytoplasm. Compared with panel C (wt), panel D shows EC shrinkage (arrowheads) and bleeding in Syk-deficient mice. The sections in panels A and C and in B and D are different sites. (F) A higher magnification image of the hemorrhagic area in panel E, which shows an erythrocyte leaking out from the vessel wall. (G,H) Tight junction structure between vascular ECs in wild-type and Syk-deficient mice, respectively (arrowheads). Bars = 2.5 μm (A-F) and 0.5 μm (G,H).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/98/9/10.1182_blood.v98.9.2869/4/h82111722002.jpeg?Expires=1726827927&Signature=O-cIrouWtfENEZcPR80eY3wAL~avrRWwQ5uw0-YTEfYExuLnGnBnp3TCCpHVW~Tvpd9~jpo-QGDuGoOPmq12VO77jAFpd97i9Y8WyZyJenrCg-5~JHw0btjVgnf77gB6SDDuwpPNKGa~RZwxSGXujavHLE-aUG16DI9xFw5UuKgoWJjehrrDD~H5CvIaZrfWr6uWNOWHfMpdgYLAZfSGkzG4cTee24jtMJ0I7S2vOnqeFYljH3e1bNwX7T1I-vItk7MyLixteKjUpFyugMrqZFi66NhVolauyL4wJ06jNLxA5n24dFk6p7PAUUe0FsHDtP7k3VGz4a~4gf6eclALlg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Electron microscopic analysis of the microvasculature of Syk-deficient mice.
Compared with panel A (wild-type [wt]), panel B shows remarkable morphologic abnormality and decreased numbers of ECs in Syk-deficient mice (Syk−). Arrowheads highlight the scanty cytoplasm. Compared with panel C (wt), panel D shows EC shrinkage (arrowheads) and bleeding in Syk-deficient mice. The sections in panels A and C and in B and D are different sites. (F) A higher magnification image of the hemorrhagic area in panel E, which shows an erythrocyte leaking out from the vessel wall. (G,H) Tight junction structure between vascular ECs in wild-type and Syk-deficient mice, respectively (arrowheads). Bars = 2.5 μm (A-F) and 0.5 μm (G,H).
