Fig. 2.
Fig. 2. Inhibition by β-GMRIT of proliferation mediated by α-GMR plus β-GMR. / BaF-3/α-GMR plus β-GMR (black square) and BaF-3/α-GMR plus β-GMR plus β-GMRIT cells (Nos. 1 through 4) were cultured with increasing concentrations of huGM-CSF, as indicated, or in the presence of mIL-3 (10 ng/mL). GM-CSF–mediated proliferation was normalized in comparison with proliferation induced by mIL-3 (100%). The background-corrected fluorescence intensity in response to mIL-3 was between 112 and 133, and background fluorescence without cytokine stimulation was lower than 5 relative fluorescence units. Untransfected cells did not exhibit any huGM-CSF–dependent proliferation.

Inhibition by β-GMRIT of proliferation mediated by α-GMR plus β-GMR.

BaF-3/α-GMR plus β-GMR (black square) and BaF-3/α-GMR plus β-GMR plus β-GMRIT cells (Nos. 1 through 4) were cultured with increasing concentrations of huGM-CSF, as indicated, or in the presence of mIL-3 (10 ng/mL). GM-CSF–mediated proliferation was normalized in comparison with proliferation induced by mIL-3 (100%). The background-corrected fluorescence intensity in response to mIL-3 was between 112 and 133, and background fluorescence without cytokine stimulation was lower than 5 relative fluorescence units. Untransfected cells did not exhibit any huGM-CSF–dependent proliferation.

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