Fig. 7.
Fig. 7. (A) The effect of coexpression of +-MITF ormi-MITF cDNA on the luciferase activity under the control of the normal or mutated Gr B promoter. Three square black boxes represent CANNTG motifs between nt −910 and +42. The boxes with X have mutated motifs: CAGATG (nt −563 to −558) motif is mutated to CTGAAG, CACGTG (nt −530 to −525) to CTCGAG, CATTTG (nt −521 to −516) to CTTTTG. The open and filled bars represent the mean ± SE of the relative luciferase activities obtained by three independent experiments. (B) The effect of coexpression of +-MITF ormi-MITF cDNA on the luciferase activity under the control of the normal, deleted, or mutated TPH promoter. Four square black boxes represent CANNTG motifs between nt −1054 and +86. The boxes with X have a mutated motif: CAGGTG (nt −322 to −317) to CTGGAG. The data represent the mean ± SE of three experiments. In some cases, the SE was too small to be shown by the bars.

(A) The effect of coexpression of +-MITF ormi-MITF cDNA on the luciferase activity under the control of the normal or mutated Gr B promoter. Three square black boxes represent CANNTG motifs between nt −910 and +42. The boxes with X have mutated motifs: CAGATG (nt −563 to −558) motif is mutated to CTGAAG, CACGTG (nt −530 to −525) to CTCGAG, CATTTG (nt −521 to −516) to CTTTTG. The open and filled bars represent the mean ± SE of the relative luciferase activities obtained by three independent experiments. (B) The effect of coexpression of +-MITF ormi-MITF cDNA on the luciferase activity under the control of the normal, deleted, or mutated TPH promoter. Four square black boxes represent CANNTG motifs between nt −1054 and +86. The boxes with X have a mutated motif: CAGGTG (nt −322 to −317) to CTGGAG. The data represent the mean ± SE of three experiments. In some cases, the SE was too small to be shown by the bars.

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