Fig. 7.
Fig. 7. Model for transcriptional regulation of human VEGF gene through an HIF-1 element under a synergistic effect of Ha-ras and hypoxia, via the activation of the PI 3-kinase, which activates Akt.

Model for transcriptional regulation of human VEGF gene through an HIF-1 element under a synergistic effect of Ha-ras and hypoxia, via the activation of the PI 3-kinase, which activates Akt.

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