Fig. 10.
Fig. 10. Comparison of rADCC induction through CD16 and CD32 expressed on human NK cells. Fresh, highly-purified NK cells from donor 1 (A) and donor 2 (B and C) as well as A-NK cells generated from donor 2 (D) were tested in the presence of KB61 anti-CD32 (1 μg/mL) or 3G8 anti-CD16 (1 μg/mL) for their ability to kill the FcP+target P815 in a 4-hour 51Cr-release cytotoxicity test at the indicated E:T ratios. NK cells from donor 2 were also tested in the presence of 32.2 anti-CD64 (1 μg/mL) (C).

Comparison of rADCC induction through CD16 and CD32 expressed on human NK cells. Fresh, highly-purified NK cells from donor 1 (A) and donor 2 (B and C) as well as A-NK cells generated from donor 2 (D) were tested in the presence of KB61 anti-CD32 (1 μg/mL) or 3G8 anti-CD16 (1 μg/mL) for their ability to kill the FcP+target P815 in a 4-hour 51Cr-release cytotoxicity test at the indicated E:T ratios. NK cells from donor 2 were also tested in the presence of 32.2 anti-CD64 (1 μg/mL) (C).

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