Fig. 1.
Inhibition of T-cell proliferation by photochemical treatment of platelet concentrates with various psoralens. The dose related effect of photochemical treatment with S-59 (□ and ▪), AMT (▵), and 8-MOP (○) on T cells in platelet concentrates was characterized. Leukocytes from photochemically treated and untreated pooled random donor platelet concentrates were plated in the LDA assay. The minimum psoralen concentrations required to inactivate T cells to the limit of detection by LDA (→) after 1.0 Joule/cm2 UVA were 0.05 μmol/L S-59, 1.0 μmol/L AMT, and 10.0 μmol/L 8-MOP. The results in Fig 1 are from two independent experiments. Arrows indicate the psoralen concentrations at which no viable T cells were found.
