Comparison of BT (Simplate) and measurement of CT with collagen-ADP and collagen-epinephrine cartridges in the PFA-100 in patients with von Willebrand disease (n = 60). Each type of vWD is identified by the following symbol: (○) type 1, (•) type 2A, (▪) type 2B, (▴) type 2N, (□) type 3, and (▵) acquired vWD. The interrupted lines represent the upper limit of the normal range (8.5 minutes) for the BT and the mean value + 2 SD of the control group for CT (120 seconds with collagen-ADP and 160 seconds with collagen-epinephrine).