Improvement of survival with AcSDKP in DOX-treated mice. Representative experiments showing the survival rates of mice (n = 30) treated with DOX either alone (closed squares) or in conjunction with AcSDKP given either 24 (open circles) or 48 hours (open squares) before the first DOX injection. (A) Continuous administration of AcSDKP (7.2 μg) by minipumps at a rate of 100 ng/h for 72 hours. (B) Discontinuous administration of AcSDKP in six injections (1.2 μg/injection) given twice daily beginning at the time indicated. The asterisk denotes a significant difference in day-30 survival compared with the control group treated with DOX alone (P < .05; Fisher's exact test).