Resting platelets interact with both endothelial P- and E-selectins in TNF-α–stimulated venules. Gel-filtered fluorescent wild-type, P−/−, or FucT IV/VII−/− platelets were transfused into wild-type, P−/−, E−/−, or P/E−/− recipient mice. The number of platelets (A) rolling and (B) captured over a 250-μm venular segment was determined; n = 5 to 9. *P < .05, **P < .01: v P/E−/−.