Fig. 7.
![Fig. 7. The IFN-γ–induced increase in high-affinity IL-12 receptor expression is mediated by IL-12. PBMC were activated with PHA, PHA + IFN-γ, or PHA + IFN-γ + anti–IL-12. Binding studies using [125I]–IL-12 were performed and the results analyzed using the Scatchard method. Similar results were obtained in three separate experiments.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/91/4/10.1182_blood.v91.4.1341/4/blod4041007.jpeg?Expires=1722820426&Signature=tI5Gboo1noCGlmXbFdWt6lyuDEBROcpGSUYuWXEpEDsRdgucNdW1zdKpZEPjpJHQ-kgD2entdI41MiYls56jVph-fueNa5FZwjABds4dyRdXJ5zkzlJldq6S8fPD~OCgdky9OSp2XOeHaYLSsYliEuAAGtgZsVDl9WD-0oSIad3Hw75jCowxzmbL9juCt92dtYJL5S8loUgUk1vpopMCLXh65IYyBGQ2US9jWB-he4hdUpaU5pKoiZggH3kijgWP69iVi7NWbrlkJXnlIX8xT2LYmqw-EJIGp8XAgu-VTRPbQRcsWRz4Qsqzt6VxMgeI2YFBEBwe5w6kr8wenEoiVg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The IFN-γ–induced increase in high-affinity IL-12 receptor expression is mediated by IL-12. PBMC were activated with PHA, PHA + IFN-γ, or PHA + IFN-γ + anti–IL-12. Binding studies using [125I]–IL-12 were performed and the results analyzed using the Scatchard method. Similar results were obtained in three separate experiments.
