WG staining of tissues from 4-5 (A, C, E) and 4-5-10 (B, D, F) that developed ALL and MPD, respectively. (A) Peripheral blood of 4-5. Massive proliferation of lymphoblasts is apparent. (B) Peripheral blood of 4-5-10. Granulocyte hyperplasia is evident. (C) Thymus of 4-5. Note the marked infiltration of lymphoblasts. (D) Bone marrow of 4-5-10. The bone marrow is hyperplastic and contains myeloid cells at various stages of differentiation. (E) Spleen of 4-5. Note infiltrating lymphoblasts. (F) Spleen of 4-5-10. Extensive infiltration of granulocytes and immature myeloid cells is apparent.