Comparison of platelet number response to PEG-rmMGDF administered intravenously as a single dose of 100 μg/kg versus daily at 100 μg/kg or 20 μg/kg for 5 days. Single dose administration of PEG-rmMGDF resulted in a higher elevation in platelet number on day 5, whereas daily dose administration produced a more prolonged thrombocytosis. No data were collected on days 7 and 12 for the 20 μg/kg dose in experiment 1 and for all doses in experiment 2. Bars represent the mean ± SEM of the platelet numbers. Numbers displayed in bars indicate number of mice in each group.