Comparison of AF6q21, AFX, and FKHR amino acid sequences. Top: Homology region within the NH2 part of the genes. Bottom: Alignment of FH domains. A HNF3 FH consensus is shown for comparison. Only amino acids identical in AF6q21, AFX, and FKHR appear in the consensus. Gaps introduced to maximize alignment are shown as dashes. Asterisks indicate identity between the FH consensus defined in this study and the HNF3 FH consensus.16 Numbering is with respect to the AF6q21 protein starting at the second in-frame ATG.