(A) Nucleotide sequence and predicted amino acid sequences of fused MLL-AF6q21 cDNAs. Fusion point is shown by arrows. (B) Genomic sequence surrounding exon 1 of AF6q21. The deduced protein is shown above the sequence. The upstream in-frame stop codon is shown by an asterisk. The longest AF6q21 cDNA isolated from the K562 cDNA library starts at nucleotide 90. Further upstream sequences are of genomic origin. Intronic sequences downstream of the putative splice site appear as lowercase letters. (C) Predicted AF6q21 protein starting at the second in-frame ATG. The NH2 region conserved with AFX and FKHR and the FH domain are underlined. The arrows border the fusion point with MLL.