American Society of Hematology

Fig. 6.

$Fig. 6. Cell cycle distribution and effect on CDK1 activity after exposure to flavopiridol. In (A), the fraction of PC3 cells in G1, S, and G2/M is indicated after 12 hours exposure to 300 nmol/L flavopiridol. The experiment shown is the mean of duplicate samples with a range of < 5% and is representative of two experiments. In (B), SUDHL4 cells were exposed to 500 nmol/L flavopiridol (•) or vehicle (▪) for the indicated time periods and CDK1 activity assayed. The experiment shown is representative of two experiments, with each kinase determination the average ± SD of three determinations. In (C), SUDHL4 cells (A) were exposed to vehicle (solid line) or 300 nmol/L flavopiridol (dashed line) for 8 hours and cell cycle distribution assayed by flow cytometry.$

Cell cycle distribution and effect on CDK1 activity after exposure to flavopiridol. In (A), the fraction of PC3 cells in G1, S, and G2/M is indicated after 12 hours exposure to 300 nmol/L flavopiridol. The experiment shown is the mean of duplicate samples with a range of < 5% and is representative of two experiments. In (B), SUDHL4 cells were exposed to 500 nmol/L flavopiridol (•) or vehicle (▪) for the indicated time periods and CDK1 activity assayed. The experiment shown is representative of two experiments, with each kinase determination the average ± SD of three determinations. In (C), SUDHL4 cells (A) were exposed to vehicle (solid line) or 300 nmol/L flavopiridol (dashed line) for 8 hours and cell cycle distribution assayed by flow cytometry.

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