The karyotypes of the jumping translocation. (A) The normal 1q21-ter (left) and the fused 1q21-ter onto the telomere of 7p (right). (B) Other fused 1q21-ter onto the telomeres of a variety of chromosomes (3q, 4p, 5q, 7p, 8q, 9q, 13q, 21q, and 22q). (C) FISH using the telomeric repeat, (TTAGGG)_n. The twin spot signals at the fusion point of der(7)t(1;7)(q21;p22) are indicated by an arrow.